Epithalong 10mg

Buy high-purity Epithalon in Australia (10mg). Third-party lab tested at >99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.

About Epithalon

Epithalon (also spelled epitalon, and sometimes referenced as "Epithalong") is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was derived from epithalamin, a polypeptide preparation of the pineal gland investigated extensively in the late twentieth century in Russian gerontology research. Epithalon distils that activity into a four-residue peptide and has since become a widely cited research compound in laboratory studies of telomere biology, circadian regulation, and cellular ageing.

Optic Labs supplies Epithalon as a lyophilised research-grade peptide for laboratories investigating telomerase activity, pineal-axis signalling, and gene-expression changes associated with senescence. Each vial is third-party HPLC verified at >99% purity. Epithalon peptide is supplied for laboratory research use only and is not intended for human consumption, cosmetic application, or any therapeutic purpose.

Product specifications

• Compound: Epithalon (Epitalon, Epithalong)
• CAS number: 307297-39-8
• Molecular formula: C₁₄H₂₂N₄O₉
• Molecular weight: ~390.35 g/mol
• Sequence: Ala-Glu-Asp-Gly (AEDG)
• Form: Lyophilised powder
• Purity: >99% by HPLC
• Available sizes: 10mg vial
• Storage: 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.
• Origin: Manufactured to research-grade specifications, third-party HPLC verified
• Shipping: Australia-wide domestic dispatch from Sydney, NSW

Research background

Epithalon was developed by Vladimir Khavinson and colleagues at the St Petersburg Institute of Bioregulation and Gerontology as a short synthetic analogue of the pineal extract epithalamin. Across several decades of laboratory and clinical-population research, it has been investigated for effects on the pineal–melatonin axis, telomere maintenance, and biomarkers of biological ageing. Modern published research continues to use Epithalon as a probe for short-peptide regulation of gene expression.

• Telomerase activity — in cell-culture studies, Epithalon has been reported to upregulate telomerase reverse transcriptase (hTERT) expression and extend telomere length in somatic cell lines.
• Pineal–melatonin axis — animal-model research has examined Epithalon's effect on pineal function, melatonin rhythm, and circadian regulation.
• Gene-expression modulation — laboratory work has explored AEDG's interaction with histones and gene-promoter regions, characterising it as an epigenetic short-peptide regulator.
• Lifespan studies in animal models — published rodent studies have explored Epithalon's effect on median and maximum lifespan, age-related mortality, and tumour incidence.
• Antioxidant and oxidative-stress markers — research has tracked changes in lipid peroxidation, glutathione, and other oxidative-stress markers in Epithalon-exposed tissue models.
• Retinal and visual-system models — preclinical investigation has examined Epithalon in models of retinal degeneration and age-related ocular change.
• Immunological ageing — laboratory studies have profiled changes in T-cell subsets and immune-marker expression in ageing animal models exposed to Epithalon.

For a more detailed research summary, see our Epithalon telomere and anti-ageing research guide and our NAD+ longevity research guide. Researchers working with reconstitution should also reference our peptide reconstitution guide.

Reconstitution and handling

Epithalon is supplied as a lyophilised powder and is reconstituted prior to use with sterile bacteriostatic water. A common laboratory approach is to add 2 mL of bac water to a 10mg vial, yielding a 5 mg/mL working concentration; at this concentration, 0.1 mL drawn into an insulin syringe corresponds to 500 µg of peptide. Reconstituted Epithalon should be stored at 2–8°C, protected from light, and used within 30 days. For step-by-step dilution mathematics, see our reconstitution calculator guide and our peptide storage research guide.

Commonly stacked research peptides

In published longevity and ageing research, Epithalon is frequently grouped with other peptides and compounds investigated for cellular-ageing, mitochondrial and antioxidant research:

• NAD+ — coenzyme central to sirtuin and DNA-repair pathways often co-studied with Epithalon in ageing research designs.
• MOTS-c — mitochondrial-derived peptide cross-referenced with Epithalon in mitochondrial ageing research.
• Glutathione — endogenous tripeptide antioxidant studied alongside Epithalon in oxidative-stress and senescence models.
• GHK-Cu — copper-binding tripeptide investigated for gene-expression and dermal-ageing research, often co-cited with Epithalon.
• CJC-1295 + Ipamorelin — GH-axis blend cross-referenced in age-related endocrine research.

For more on multi-peptide research designs, see our peptide research stacks overview.

Frequently asked questions

Is Epithalon legal in Australia?

Epithalon is supplied by Optic Labs strictly for laboratory research, development and analytical use. It is not approved by the Therapeutic Goods Administration for human therapeutic use and is not a registered medicine. For a detailed overview of Australian peptide research regulation, see our guide to peptide legality and TGA compliance in Australia.

What is Epithalon?

Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), originally derived from the pineal-gland polypeptide complex epithalamin. It is investigated in laboratory research as a regulator of telomerase activity and gene expression. See our Epithalon telomere research guide for a deeper overview.

Is Epithalon the same as Epitalon or Epithalong?

Yes — "Epithalon", "Epitalon" and "Epithalong" are spelling variants of the same AEDG tetrapeptide. They refer to the same compound across English, Russian transliteration, and various supplier brand names.

How is Epithalon supplied?

Optic Labs supplies Epithalon as a lyophilised powder in glass research vials, available in 10mg. Each vial is sealed and shipped with a tamper-evident seal. Certificates of analysis showing HPLC purity testing are available on request.

How much bacteriostatic water do I mix with an Epithalon 10mg vial?

A common laboratory dilution is 2 mL of bacteriostatic water per 10mg vial, giving a 5 mg/mL solution. The exact volume depends on your research protocol — see our reconstitution calculator guide for dilution mathematics.

How should reconstituted Epithalon be stored?

Reconstituted Epithalon should be kept at 2–8°C, protected from light, and used within 30 days. Long-term storage of unreconstituted lyophilised powder should be at −20°C or colder. See our peptide storage complete research guide for handling detail.

Where does Optic Labs ship to?

Optic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.

Legal disclaimer

All products on this site are supplied for laboratory research, development or analytical use only. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the Therapeutic Goods Administration (TGA) or the APVMA and are not intended to diagnose, treat, cure or prevent any disease. Optic Labs is not a compounding pharmacy or manufacturing facility as defined under the Therapeutic Goods Act 1989, and is not a registered provider of scheduled medicines or therapeutic goods.