{"product_id":"glutathione-1500mg","title":"Glutathione 1500mg","description":"\u003cp\u003e\u003cstrong\u003eBuy high-purity glutathione (1500mg) in Australia. Third-party lab tested at \u0026gt;99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch2\u003eAbout glutathione\u003c\/h2\u003e\n\u003cp\u003eGlutathione (GSH) is an endogenous tripeptide composed of glutamate, cysteine and glycine, present in virtually every mammalian cell. It is the principal low-molecular-weight thiol antioxidant in eukaryotic cells and is central to redox homeostasis, phase II detoxification and the regulation of intracellular cysteine pools.\u003c\/p\u003e\n\n\u003cp\u003eIn published research, glutathione is most often studied in the context of oxidative stress, hepatic detoxification pathways, immune cell function and mitochondrial redox status.\u003c\/p\u003e\n\u003cp\u003eOptic Labs supplies glutathione as a lyophilised powder in 1500mg research vials, third-party HPLC tested to \u0026gt;99% purity. The product is distributed Australian-domestic from Sydney, NSW, for in vitro and laboratory research applications. Glutathione is supplied strictly for laboratory research, development or analytical use and is not intended for human consumption.\u003c\/p\u003e\n\n\u003ch2\u003eProduct specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound:\u003c\/strong\u003e L-Glutathione (reduced; γ-L-glutamyl-L-cysteinyl-glycine)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 70-18-8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C\u003csub\u003e10\u003c\/sub\u003eH\u003csub\u003e17\u003c\/sub\u003eN\u003csub\u003e3\u003c\/sub\u003eO\u003csub\u003e6\u003c\/sub\u003eS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e ~307.32 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e γ-Glu-Cys-Gly (tripeptide)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% by HPLC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable size:\u003c\/strong\u003e 1500mg vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Manufactured to research-grade specifications, third-party HPLC verified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Australia-wide domestic dispatch from Sydney, NSW\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eResearch background\u003c\/h2\u003e\n\u003cp\u003eGlutathione was first isolated from yeast in 1888 and structurally characterised in the 1920s by Frederick Gowland Hopkins, who established its tripeptide identity. Since then it has become one of the most extensively studied small molecules in biochemistry, with the GSH\/GSSG (reduced\/oxidised) ratio used as a standard biomarker of intracellular redox state in cell-culture and animal model research.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant defence:\u003c\/strong\u003e in cell-culture studies, glutathione donates electrons via glutathione peroxidase (GPx) to neutralise hydrogen peroxide and lipid peroxides, with oxidised GSSG recycled by glutathione reductase using NADPH.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhase II detoxification:\u003c\/strong\u003e in hepatocyte and liver-tissue research, glutathione conjugation via glutathione S-transferases (GSTs) is a primary mechanism for clearing electrophilic xenobiotics, including paracetamol-derived NAPQI in animal toxicology models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial redox:\u003c\/strong\u003e mitochondrial glutathione (mtGSH) is studied in models of oxidative phosphorylation dysfunction, complex I inhibition and age-related mitochondrial decline.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune cell function:\u003c\/strong\u003e in T-cell and macrophage research, intracellular GSH levels modulate cytokine profiles, NF-κB signalling and proliferation under oxidative challenge.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein S-glutathionylation:\u003c\/strong\u003e reversible binding of GSH to protein cysteine residues is a regulatory post-translational modification studied in cardiac, neuronal and skeletal muscle models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlutathione depletion models:\u003c\/strong\u003e buthionine sulfoximine (BSO) is used in rodent and cell research to inhibit γ-glutamylcysteine synthetase and study GSH depletion phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin and melanocyte cell research:\u003c\/strong\u003e in cell-culture studies, glutathione has been examined for its role in tyrosinase activity and pheomelanin\/eumelanin balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor a more detailed research summary, see our \u003ca href=\"\/blogs\/news\/glutathione-australia-antioxidant-research-guide\"\u003eglutathione antioxidant research guide\u003c\/a\u003e and our \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e. Researchers working with reconstitution should also reference our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003epeptide reconstitution guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eReconstitution and handling\u003c\/h2\u003e\n\u003cp\u003eUnlike most short-chain research peptides, glutathione is highly water-soluble and can be reconstituted at relatively high concentrations. A common laboratory approach for the 1500mg vial is reconstitution in 5ml of \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e to yield a 300mg\/ml working stock, or in 10ml for a 150mg\/ml stock.\u003c\/p\u003e\n\n\u003cp\u003eGlutathione is sensitive to oxidation in solution, particularly at neutral and alkaline pH, so reconstituted solutions should be aliquoted, kept refrigerated at 2–8°C and protected from light. For dilution maths across alternative volumes, see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e. For long-term storage protocols, see our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eCommonly stacked research peptides\u003c\/h2\u003e\n\u003cp\u003eIn published research and laboratory protocols, glutathione is often examined alongside other antioxidant, longevity and mitochondrial-function compounds:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/nad-1000mg\"\u003eNAD+\u003c\/a\u003e — co-investigated in mitochondrial redox and longevity research; NAD+ supports the NADPH pool that regenerates reduced glutathione.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/ss-31-10mg\"\u003eSS-31\u003c\/a\u003e — mitochondrial-targeted peptide commonly studied alongside GSH in oxidative phosphorylation and cardiolipin protection models.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/mots-c-10mg-40mg\"\u003eMOTS-c\u003c\/a\u003e — mitochondrial-derived peptide investigated for metabolic and redox effects in parallel with glutathione status.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/ghk-cu-50mg-100mg\"\u003eGHK-Cu\u003c\/a\u003e — copper peptide studied alongside glutathione in skin, fibroblast and antioxidant gene-expression research.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/epithalong-10mg\"\u003eEpithalon\u003c\/a\u003e — telomere and longevity research peptide frequently grouped with GSH in anti-ageing study designs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor broader context on combined research designs, see our \u003ca href=\"\/blogs\/news\/peptide-research-stacks-australia-combinations\"\u003epeptide research stacks overview\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\n\u003ch3\u003eIs glutathione legal in Australia?\u003c\/h3\u003e\n\u003cp\u003eGlutathione is a naturally occurring tripeptide and is not a scheduled substance under the Australian Poisons Standard. However, products supplied for laboratory research are regulated differently from therapeutic goods. Optic Labs supplies glutathione strictly for laboratory, research and analytical use only, not as a therapeutic good.\u003c\/p\u003e\n\n\u003cp\u003eFor a full overview of how the Therapeutic Goods Administration treats research peptides in Australia, see our \u003ca href=\"\/blogs\/news\/are-peptides-legal-australia-tga-compliance-2025\"\u003epeptide legality and TGA compliance guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat is glutathione?\u003c\/h3\u003e\n\u003cp\u003eGlutathione is a tripeptide of glutamate, cysteine and glycine, found at high intracellular concentrations in virtually all mammalian cells. It is the body's major non-enzymatic thiol antioxidant and a central substrate in phase II liver detoxification. For a plain-language overview of peptides and how they differ from small-molecule drugs, see our \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat does glutathione do in published research?\u003c\/h3\u003e\n\u003cp\u003eIn published in vitro and animal research, glutathione is studied as an electron donor for glutathione peroxidase (neutralising peroxides), as a conjugation partner in xenobiotic clearance via glutathione S-transferases, as a regulator of protein function via reversible S-glutathionylation, and as a marker of redox state through the GSH\/GSSG ratio.\u003c\/p\u003e\n\n\u003cp\u003eResearchers also examine its role in mitochondrial redox balance and immune cell signalling. These observations are research findings only and do not constitute therapeutic claims.\u003c\/p\u003e\n\n\u003ch3\u003eWhat is typically considered when working with glutathione in solution?\u003c\/h3\u003e\n\u003cp\u003eResearchers commonly account for glutathione's susceptibility to oxidation in aqueous solution, particularly at neutral or alkaline pH and in the presence of trace metals. Working stocks are usually prepared fresh, aliquoted to minimise freeze-thaw cycles, kept cold and shielded from light. In cell-culture work, GSH is often paired with chelators or prepared in degassed buffer to limit auto-oxidation prior to assay.\u003c\/p\u003e\n\n\u003ch3\u003eHow is glutathione supplied?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs supplies glutathione as a lyophilised powder in glass research vials at a 1500mg fill. Each vial is sealed with a tamper-evident closure. Certificates of analysis showing HPLC purity testing are available on request.\u003c\/p\u003e\n\n\u003ch3\u003eHow much bacteriostatic water do I mix with a 1500mg glutathione vial?\u003c\/h3\u003e\n\u003cp\u003eFor a 1500mg vial, 5ml of \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e yields a 300mg\/ml working stock; 10ml yields a 150mg\/ml stock; 15ml yields a 100mg\/ml stock. Choose a volume based on the concentrations required by the research protocol. For a step-by-step worked example with unit conversions, see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHow should reconstituted glutathione be stored?\u003c\/h3\u003e\n\u003cp\u003eReconstituted glutathione should be stored at 2–8°C, protected from light, and used within approximately 30 days. For longer-term storage, aliquoting and freezing at −20°C or below is preferred to limit oxidation and freeze-thaw degradation. Full handling protocols are covered in our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhere does Optic Labs ship to?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.\u003c\/p\u003e\n\n\u003ch2\u003eLegal disclaimer\u003c\/h2\u003e\n\u003cp\u003eAll products on this site are supplied for \u003cstrong\u003elaboratory research, development or analytical use only\u003c\/strong\u003e. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the \u003cstrong\u003eTherapeutic Goods Administration (TGA)\u003c\/strong\u003e or the \u003cstrong\u003eAPVMA\u003c\/strong\u003e and are not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\n\n\u003cp\u003eOptic Labs is not a \u003cstrong\u003ecompounding pharmacy\u003c\/strong\u003e or manufacturing facility as defined under the \u003cem\u003eTherapeutic Goods Act 1989\u003c\/em\u003e, and is not a registered provider of scheduled medicines or therapeutic goods.\u003c\/p\u003e","brand":"Optic Labs","offers":[{"title":"Default Title","offer_id":53360884678840,"sku":null,"price":94.99,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0952\/4196\/1656\/files\/glutathione_55dfce13-ce84-4a3a-824e-b3aab73ebb2a.png?v=1776428196","url":"https:\/\/opticlabsau.com\/products\/glutathione-1500mg","provider":"Optic Labs","version":"1.0","type":"link"}