{"product_id":"kpv-10mg","title":"KPV 10mg","description":"\u003cp\u003e\u003cstrong\u003eBuy high-purity KPV in Australia (10mg). Third-party lab tested at \u0026gt;99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch2\u003eAbout KPV\u003c\/h2\u003e\n\u003cp\u003eKPV is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH), composed of the sequence lysine–proline–valine. The peptide retains many of the anti-inflammatory and immunomodulatory characteristics attributed to the parent α-MSH molecule, but in a much smaller, more chemically tractable form. KPV has become a focal point for laboratory investigation of melanocortin-pathway-independent anti-inflammatory mechanisms, particularly in epithelial and mucosal tissue models.\u003c\/p\u003e\n\u003cp\u003eOptic Labs supplies KPV as a lyophilised research-grade powder for laboratories investigating gut-barrier integrity, dermal inflammation, mast-cell behaviour, and innate-immune signalling. Each vial is third-party HPLC verified at \u0026gt;99% purity. KPV peptide is supplied for laboratory research use only and is not intended for human consumption, cosmetic application, or any therapeutic purpose.\u003c\/p\u003e\n\n\u003ch2\u003eProduct specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound:\u003c\/strong\u003e KPV (Lysine–Proline–Valine)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 67727-97-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C\u003csub\u003e16\u003c\/sub\u003eH\u003csub\u003e30\u003c\/sub\u003eN\u003csub\u003e4\u003c\/sub\u003eO\u003csub\u003e4\u003c\/sub\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e ~342.4 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Pro-Val (KPV)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% by HPLC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable sizes:\u003c\/strong\u003e 10mg vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Manufactured to research-grade specifications, third-party HPLC verified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Australia-wide domestic dispatch from Sydney, NSW\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eResearch background\u003c\/h2\u003e\n\u003cp\u003eKPV was first characterised in the 1980s and 1990s as a minimal active fragment of α-MSH (α-melanocyte-stimulating hormone), retaining anti-inflammatory activity in the apparent absence of melanocortin-receptor binding. This made KPV an unusual research tool — a small peptide capable of modulating inflammation through receptor-independent intracellular pathways. Since then, the peptide has appeared across multiple lines of preclinical inflammation research.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNF-κB pathway modulation\u003c\/strong\u003e — in cell-culture studies, KPV has been reported to interfere with NF-κB nuclear translocation, an upstream regulator of pro-inflammatory cytokine transcription.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eColitis and gut-barrier models\u003c\/strong\u003e — published animal studies in DSS- and TNBS-induced colitis have explored KPV as a candidate for restoring intestinal epithelial integrity and reducing mucosal inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMast-cell activity\u003c\/strong\u003e — preclinical work has examined the peptide's effect on mast-cell degranulation and histamine-mediated inflammatory cascades.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDermal and atopic models\u003c\/strong\u003e — KPV has been investigated topically in animal models of contact dermatitis and atopic-style skin inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePepT1 transporter uptake\u003c\/strong\u003e — research has characterised KPV as a substrate for the intestinal PepT1 di\/tripeptide transporter, supporting its use in oral-delivery research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCytokine profiling\u003c\/strong\u003e — laboratory investigations have profiled changes in TNF-α, IL-6, and IL-1β following KPV exposure in inflammatory cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-microbial activity\u003c\/strong\u003e — fragment-based research has reported activity against certain dermatophyte and yeast species in vitro.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor a more detailed research summary, see our \u003ca href=\"\/blogs\/news\/kpv-peptide-australia-anti-inflammatory-research\"\u003eKPV anti-inflammatory research guide\u003c\/a\u003e and our broader \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e. Researchers working with reconstitution should also reference our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003epeptide reconstitution guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eReconstitution and handling\u003c\/h2\u003e\n\u003cp\u003eKPV is supplied as a lyophilised powder and is reconstituted prior to use with sterile \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e. A common laboratory approach is to add 2 mL of bac water to a 10mg vial, yielding a 5 mg\/mL working concentration; at this concentration, 0.1 mL drawn into an insulin syringe corresponds to 500 µg of peptide. Reconstituted KPV should be stored at 2–8°C, protected from light, and used within 30 days. For step-by-step dilution mathematics, see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e and our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eCommonly stacked research peptides\u003c\/h2\u003e\n\u003cp\u003eIn published stack-design literature, KPV is frequently grouped with other peptides under investigation for tissue-repair, gut-barrier, and skin-inflammation research. Researchers commonly cross-reference:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/bpc-157\"\u003eBPC-157\u003c\/a\u003e — gastric-derived pentadecapeptide investigated for gut-barrier and angiogenesis research, often paired with KPV in mucosal-integrity work.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/tb-500\"\u003eTB-500\u003c\/a\u003e — thymosin β4 fragment used in tissue-repair research, complementing KPV in injury and inflammation models.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/ghk-cu-50mg-100mg\"\u003eGHK-Cu\u003c\/a\u003e — copper-binding tripeptide investigated for dermal remodelling, often referenced alongside KPV in skin-inflammation research.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/klow80-bpc-157-10mg-ghk-cu-50mg-tb-500-10mg-kpv-10mg\"\u003eKLOW80 stack\u003c\/a\u003e — pre-formulated combination of BPC-157, GHK-Cu, TB-500 and KPV used in stack-design research.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/glutathione-1500mg\"\u003eGlutathione\u003c\/a\u003e — tripeptide antioxidant cross-referenced with KPV in redox and inflammation research designs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor more on multi-peptide research designs, see our \u003ca href=\"\/blogs\/news\/peptide-research-stacks-australia-combinations\"\u003epeptide research stacks overview\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\n\u003ch3\u003eIs KPV legal in Australia?\u003c\/h3\u003e\n\u003cp\u003eKPV is supplied by Optic Labs strictly for laboratory research, development and analytical use. It is not approved by the Therapeutic Goods Administration for human therapeutic use and is not a registered medicine. For a detailed overview of Australian peptide research regulation, see our \u003ca href=\"\/blogs\/news\/are-peptides-legal-australia-tga-compliance-2025\"\u003eguide to peptide legality and TGA compliance in Australia\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat is KPV?\u003c\/h3\u003e\n\u003cp\u003eKPV is a synthetic tripeptide consisting of the amino acids lysine, proline and valine — the C-terminal three residues of α-melanocyte-stimulating hormone (α-MSH). It is studied in laboratory research for its anti-inflammatory and immunomodulatory characteristics. See our \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e for broader context.\u003c\/p\u003e\n\n\u003ch3\u003eWhat does KPV research focus on?\u003c\/h3\u003e\n\u003cp\u003ePublished research has examined KPV in cell-culture and animal models of intestinal inflammation, dermatitis, mast-cell activation and NF-κB-mediated cytokine signalling. The peptide is studied as a small, receptor-independent anti-inflammatory tool rather than a melanocortin-pathway agonist.\u003c\/p\u003e\n\n\u003ch3\u003eHow is KPV supplied?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs supplies KPV as a lyophilised powder in glass research vials, available in 10mg. Each vial is sealed and shipped with a tamper-evident seal. Certificates of analysis showing HPLC purity testing are available on request.\u003c\/p\u003e\n\n\u003ch3\u003eHow much bacteriostatic water do I mix with a KPV 10mg vial?\u003c\/h3\u003e\n\u003cp\u003eA common laboratory dilution is 2 mL of \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e per 10mg vial, giving a 5 mg\/mL solution. The exact volume depends on your research protocol — see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e for dilution mathematics.\u003c\/p\u003e\n\n\u003ch3\u003eHow should reconstituted KPV be stored?\u003c\/h3\u003e\n\u003cp\u003eReconstituted KPV should be kept at 2–8°C, protected from light, and used within 30 days. Long-term storage of unreconstituted lyophilised powder should be at −20°C or colder. See our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage complete research guide\u003c\/a\u003e for handling detail.\u003c\/p\u003e\n\n\u003ch3\u003eWhere does Optic Labs ship to?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.\u003c\/p\u003e\n\n\u003ch2\u003eLegal disclaimer\u003c\/h2\u003e\n\u003cp\u003eAll products on this site are supplied for \u003cstrong\u003elaboratory research, development or analytical use only\u003c\/strong\u003e. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the \u003cstrong\u003eTherapeutic Goods Administration (TGA)\u003c\/strong\u003e or the \u003cstrong\u003eAPVMA\u003c\/strong\u003e and are not intended to diagnose, treat, cure or prevent any disease. Optic Labs is not a \u003cstrong\u003ecompounding pharmacy\u003c\/strong\u003e or manufacturing facility as defined under the \u003cem\u003eTherapeutic Goods Act 1989\u003c\/em\u003e, and is not a registered provider of scheduled medicines or therapeutic goods.\u003c\/p\u003e","brand":"Optic Labs","offers":[{"title":"Default Title","offer_id":53360884515000,"sku":null,"price":61.99,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0952\/4196\/1656\/files\/kpv10.png?v=1776426193","url":"https:\/\/opticlabsau.com\/products\/kpv-10mg","provider":"Optic Labs","version":"1.0","type":"link"}