{"product_id":"semax-10mg","title":"Semax 10mg","description":"\u003cp\u003e\u003cstrong\u003eBuy high-purity semax (10mg) in Australia. Third-party lab tested at \u0026gt;99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch2\u003eAbout semax\u003c\/h2\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide developed at the Russian Academy of Sciences and the Institute of Molecular Genetics in the late 1980s. Its sequence (Met-Glu-His-Phe-Pro-Gly-Pro) is a fragment analogue of the N-terminal of adrenocorticotropic hormone (ACTH 4–7), modified with a C-terminal Pro-Gly-Pro tripeptide that markedly extends its plasma stability. In published research, semax is one of the most extensively studied nootropic and neuroprotective research peptides in the Russian and Eastern European scientific literature, with research interest in its effects on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and the dopaminergic and serotonergic systems.\u003c\/p\u003e\n\u003cp\u003eOptic Labs supplies semax as a lyophilised powder in 10mg research vials, third-party HPLC tested to \u0026gt;99% purity. The product is distributed Australian-domestic from Sydney, NSW, for in vitro and laboratory research applications. Semax is supplied strictly for laboratory research, development or analytical use and is not intended for human consumption.\u003c\/p\u003e\n\n\u003ch2\u003eProduct specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound:\u003c\/strong\u003e Semax (ACTH 4–7 PGP analogue)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 80714-61-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C\u003csub\u003e37\u003c\/sub\u003eH\u003csub\u003e51\u003c\/sub\u003eN\u003csub\u003e9\u003c\/sub\u003eO\u003csub\u003e10\u003c\/sub\u003eS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e ~813.93 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Met-Glu-His-Phe-Pro-Gly-Pro\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% by HPLC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable size:\u003c\/strong\u003e 10mg vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Manufactured to research-grade specifications, third-party HPLC verified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Australia-wide domestic dispatch from Sydney, NSW\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eResearch background\u003c\/h2\u003e\n\u003cp\u003eSemax was developed by Russian researchers as a non-hormonal analogue of ACTH 4–10, retaining behavioural and neurotrophic activity while removing corticotropic effects. The C-terminal Pro-Gly-Pro extension provides resistance to enzymatic degradation, which gives semax an unusually long functional half-life for a small peptide. Semax is registered as a medicine in the Russian Federation but, in the Australian and Western research context, it is studied as a research-use compound.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBDNF and neurotrophic signalling:\u003c\/strong\u003e in rodent brain-tissue research, semax administration has been associated with rapid increases in BDNF and NGF expression, particularly in the hippocampus and basal forebrain.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive performance models:\u003c\/strong\u003e in animal models of learning and memory, semax has been investigated for effects on attention, working memory and behavioural flexibility under cognitive load.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCerebral ischaemia research:\u003c\/strong\u003e in rodent stroke and middle cerebral artery occlusion (MCAO) models, semax has been studied as a neuroprotective candidate, with research interest in infarct volume, oxidative stress markers and neurological recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDopaminergic and serotonergic modulation:\u003c\/strong\u003e in receptor-binding and microdialysis studies, semax has been examined for modulation of dopamine and serotonin turnover in striatal and cortical tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnkephalin system interactions:\u003c\/strong\u003e in published research, semax administration has been associated with elevated enkephalin levels, providing a candidate mechanism for some of its anxiolytic-like effects in animal models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant gene expression:\u003c\/strong\u003e in cell-culture and brain-tissue studies, semax has been associated with up-regulation of genes involved in cellular antioxidant defence.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePharmacokinetic stability:\u003c\/strong\u003e in published research, the Pro-Gly-Pro modification gives semax substantially longer functional activity than the parent ACTH 4–10 fragment, supporting its position as one of the more practically usable nootropic research peptides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor a more detailed research summary, see our \u003ca href=\"\/blogs\/news\/semax-australia-nootropic-research-guide\"\u003esemax nootropic research guide\u003c\/a\u003e and our \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e. Researchers working with reconstitution should also reference our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003epeptide reconstitution guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eReconstitution and handling\u003c\/h2\u003e\n\u003cp\u003eSemax is highly water-soluble and reconstitutes readily. A common laboratory approach for the 10mg vial is reconstitution in 2ml of \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e to yield a 5mg\/ml working stock, or in 1ml for a 10mg\/ml stock. The bacteriostatic water should be drawn into a sterile syringe and injected slowly down the inside wall of the lyophilised vial, allowing the peptide cake to dissolve passively rather than through agitation. Reconstituted semax should be aliquoted, refrigerated at 2–8°C and protected from light, with research stocks typically used within 30 days. For dilution maths across alternative volumes, see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e. For long-term storage protocols, see our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eCommonly stacked research peptides\u003c\/h2\u003e\n\u003cp\u003eIn published research and laboratory protocols, semax is often examined alongside other nootropic, anxiolytic and longevity research compounds:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/selank-10mg\"\u003eSelank\u003c\/a\u003e — anxiolytic heptapeptide developed by the same research group; commonly co-investigated with semax in stress and cognitive performance models.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/dsip-10mg-15mg\"\u003eDSIP\u003c\/a\u003e — delta sleep-inducing peptide examined alongside semax in studies of sleep architecture and stress recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/nad-1000mg\"\u003eNAD+\u003c\/a\u003e — co-investigated in neuronal energetics and longevity research.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/epithalong-10mg\"\u003eEpithalon\u003c\/a\u003e — telomere and longevity research peptide commonly grouped with semax in anti-ageing study designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/products\/mots-c-10mg-40mg\"\u003eMOTS-c\u003c\/a\u003e — mitochondrial-derived peptide examined in parallel with semax in research on neuronal energy metabolism.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor broader context on combined research designs, see our \u003ca href=\"\/blogs\/news\/peptide-research-stacks-australia-combinations\"\u003epeptide research stacks overview\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\n\u003ch3\u003eIs semax legal in Australia?\u003c\/h3\u003e\n\u003cp\u003eSemax is not a scheduled substance under the Australian Poisons Standard, but it is also not registered as a therapeutic good in Australia. Optic Labs supplies semax strictly for laboratory, research and analytical use only, not as a therapeutic good. For a full overview of how the Therapeutic Goods Administration treats research peptides in Australia, see our \u003ca href=\"\/blogs\/news\/are-peptides-legal-australia-tga-compliance-2025\"\u003epeptide legality and TGA compliance guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat is semax?\u003c\/h3\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide analogue of ACTH 4–7, modified with a C-terminal Pro-Gly-Pro tripeptide for enzymatic stability. It is one of the most extensively studied nootropic research peptides in Russian and Eastern European scientific literature. For a plain-language overview of peptides, see our \u003ca href=\"\/blogs\/news\/what-are-peptides-australia-explainer\"\u003ewhat are peptides explainer\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhat does semax do in published research?\u003c\/h3\u003e\n\u003cp\u003eIn published research, semax is studied for its effects on BDNF and NGF expression, dopaminergic and serotonergic neurotransmission, cerebral ischaemia outcomes in rodent stroke models, and cognitive performance in animal models of learning and memory. These observations are research findings only and do not constitute therapeutic claims. For a research-level summary, see our \u003ca href=\"\/blogs\/news\/semax-australia-nootropic-research-guide\"\u003esemax nootropic research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHow does semax compare with selank in research?\u003c\/h3\u003e\n\u003cp\u003eSemax and selank were both developed by the same Russian research group as Pro-Gly-Pro-stabilised heptapeptides, but they target distinct research areas. Semax is primarily examined for nootropic and neuroprotective effects via the BDNF\/NGF axis. \u003ca href=\"\/products\/selank-10mg\"\u003eSelank\u003c\/a\u003e is more often investigated for anxiolytic-like effects via GABAergic and tuftsin-related pathways. The two are frequently co-studied in stress and cognitive performance models.\u003c\/p\u003e\n\n\u003ch3\u003eHow is semax supplied?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs supplies semax as a lyophilised powder in 10mg glass research vials. Each vial is sealed with a tamper-evident closure. Certificates of analysis showing HPLC purity testing are available on request.\u003c\/p\u003e\n\n\u003ch3\u003eHow much bacteriostatic water do I mix with a 10mg semax vial?\u003c\/h3\u003e\n\u003cp\u003eFor a 10mg vial, 2ml of \u003ca href=\"\/products\/bac-water-3ml-10ml\"\u003ebacteriostatic water\u003c\/a\u003e yields a 5mg\/ml working stock; 1ml yields a 10mg\/ml stock; 5ml yields a 2mg\/ml stock. Choose a volume based on the concentrations required by the research protocol. For a worked example with unit conversions, see our \u003ca href=\"\/blogs\/news\/peptide-reconstitution-calculator-guide-australia\"\u003ereconstitution calculator guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eHow should reconstituted semax be stored?\u003c\/h3\u003e\n\u003cp\u003eReconstituted semax should be stored at 2–8°C, protected from light, and used within approximately 30 days. For longer-term storage, aliquoting and freezing at −20°C or below is preferred to limit freeze-thaw degradation. Full handling protocols are covered in our \u003ca href=\"\/blogs\/news\/peptide-storage-complete-research-guide\"\u003epeptide storage research guide\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch3\u003eWhere does Optic Labs ship to?\u003c\/h3\u003e\n\u003cp\u003eOptic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.\u003c\/p\u003e\n\n\u003ch2\u003eLegal disclaimer\u003c\/h2\u003e\n\u003cp\u003eAll products on this site are supplied for \u003cstrong\u003elaboratory research, development or analytical use only\u003c\/strong\u003e. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the \u003cstrong\u003eTherapeutic Goods Administration (TGA)\u003c\/strong\u003e or the \u003cstrong\u003eAPVMA\u003c\/strong\u003e and are not intended to diagnose, treat, cure or prevent any disease. Optic Labs is not a \u003cstrong\u003ecompounding pharmacy\u003c\/strong\u003e or manufacturing facility as defined under the \u003cem\u003eTherapeutic Goods Act 1989\u003c\/em\u003e, and is not a registered provider of scheduled medicines or therapeutic goods.\u003c\/p\u003e","brand":"Optic Labs","offers":[{"title":"Default Title","offer_id":53360884220088,"sku":null,"price":61.99,"currency_code":"AUD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0952\/4196\/1656\/files\/semax.png?v=1776426119","url":"https:\/\/opticlabsau.com\/products\/semax-10mg","provider":"Optic Labs","version":"1.0","type":"link"}