SS-31 10mg

Buy high-purity SS-31 in Australia (10mg). Third-party lab tested at >99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.

About SS-31

SS-31 (also known as elamipretide, MTP-131 or Bendavia) is a small mitochondria-targeted tetrapeptide developed in the laboratory of Hazel Szeto and Peter Schiller. The sequence — D-Arg-2',6'-dimethylTyr-Lys-Phe-NH₂ — is engineered to selectively concentrate in the inner mitochondrial membrane, where it associates with cardiolipin and has been characterised for its effects on electron-transport efficiency, reactive oxygen species and ATP production in published research.

SS-31 has become one of the most widely cited tools in mitochondrial-protection research over the past decade.

Optic Labs supplies SS-31 in Australia as a lyophilised powder, 10mg per vial, third-party HPLC verified at >99% purity. The compound is provided strictly for laboratory research, including in-vitro mitochondrial function assays, cell-culture oxidative-stress models and animal studies of cardiac, renal, neurological and ageing biology. SS-31 is supplied for research use only and is not intended for human consumption, clinical, cosmetic, diagnostic or veterinary application.

Product specifications

• Compound: SS-31 (elamipretide, MTP-131)
• CAS number: 736992-21-5
• Molecular formula: C₃₂H₄₉N₉O₅
• Molecular weight: ~639.8 g/mol
• Sequence: D-Arg-Dmt-Lys-Phe-NH₂ (D-Arg-2',6'-dimethylTyr-Lys-Phe amide)
• Form: Lyophilised powder
• Purity: >99% by HPLC
• Available sizes: 10mg vial
• Storage: 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.
• Origin: Manufactured to research-grade specifications, third-party HPLC verified
• Shipping: Australia-wide domestic dispatch from Sydney, NSW

Research background

SS-31 was first described in the early 2000s as part of the Szeto-Schiller (SS) series of cell-permeable, mitochondria-targeted antioxidant peptides. Unlike triphenylphosphonium-conjugated antioxidants, SS-31 concentrates in the inner mitochondrial membrane independent of membrane potential, where it interacts with cardiolipin. This pharmacophore has driven a sustained body of preclinical and clinical research into mitochondrial dysfunction.

• Cardiolipin binding and stabilisation of inner-mitochondrial-membrane cristae architecture in isolated mitochondria and cell-culture models.
• Reductions in mitochondrial reactive oxygen species (ROS) generation and improved electron-transport-chain coupling in ischaemia-reperfusion models.
• Cardioprotection in rodent models of myocardial infarction, heart failure and doxorubicin-induced cardiotoxicity.
• Renal-protection studies in models of acute kidney injury, ischaemia-reperfusion and chronic kidney disease.
• Neuroprotective signals in animal models of Parkinson's disease, traumatic brain injury and age-related cognitive decline.
• Skeletal-muscle research in ageing and disuse-atrophy models examining mitochondrial bioenergetics and fatigue resistance.
• Investigation in primary mitochondrial diseases including Barth syndrome and mitochondrial myopathies through clinical research programmes.

For broader mitochondrial-research context, see our SS-31 mitochondrial protection research guide and our MOTS-c mitochondrial peptide guide. Researchers working with reconstitution should also reference our peptide reconstitution guide.

Reconstitution and handling

SS-31 is supplied lyophilised and should be reconstituted with sterile bacteriostatic water for laboratory use. A common working approach is to add 2mL of bacteriostatic water to a 10mg vial, yielding a 5mg/mL stock; 1mL gives 10mg/mL for more concentrated workflows.

Add the diluent slowly down the side of the vial — do not inject directly onto the lyophilised cake — and allow the powder to dissolve without vigorous shaking. Reconstituted SS-31 should be stored at 2–8°C, protected from light, and used within 30 days.

For a step-by-step volume calculator and worked examples for any vial size, see our peptide reconstitution calculator guide and our peptide storage guide.

Commonly stacked research peptides

SS-31 is frequently studied alongside other peptides relevant to mitochondrial function, longevity and tissue-repair pathways:

• MOTS-c — mitochondrial-derived peptide examined in metabolic and exercise-mimetic research, complementary to SS-31 in mitochondrial-bioenergetics studies.
• NAD+ — coenzyme central to electron transport and sirtuin signalling; commonly paired in mitochondrial-longevity research designs.
• Epithalon — AEDG tetrapeptide investigated in telomerase and ageing-biology models.
• Glutathione — endogenous antioxidant tripeptide, often used as a reference compound in oxidative-stress assays.
• GHK-Cu — copper-binding tripeptide studied in mitochondrial-gene-expression and tissue-regeneration research.

For broader stack-design context, see our peptide research stacks overview.

Frequently asked questions

Is SS-31 legal in Australia?

SS-31 is not an approved therapeutic good in Australia and is not registered with the Therapeutic Goods Administration (TGA). Optic Labs supplies SS-31 strictly for laboratory research, development and analytical use — not for human consumption, clinical or cosmetic application. For a detailed overview of how research peptides sit within the Australian regulatory framework, see our guide to peptide legality and TGA compliance in Australia.

What is SS-31?

SS-31 is a synthetic mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH₂), also known as elamipretide or MTP-131. It is one of the Szeto-Schiller series of peptides developed to concentrate in the inner mitochondrial membrane and interact with cardiolipin. For a plain-language overview of peptide structure and research use, see our what are peptides explainer.

How does SS-31 differ from MOTS-c in mitochondrial research?

Both compounds are studied in mitochondrial-function research but operate differently. SS-31 is a synthetic, mitochondria-targeted tetrapeptide that concentrates at cardiolipin in the inner mitochondrial membrane and is investigated for effects on cristae architecture, ROS and electron transport.

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA, studied as a metabolic regulator that signals to the nucleus. Researchers often examine the two in parallel rather than as substitutes — see our MOTS-c research guide for context.

How much bacteriostatic water do I mix with an SS-31 10mg vial?

For a 10mg vial, 2mL of bacteriostatic water gives a 5mg/mL stock; 1mL gives 10mg/mL. Choose the dilution that matches the volumes typical of your research protocol. See our reconstitution calculator guide for worked examples.

How should reconstituted SS-31 be stored?

Reconstituted SS-31 should be stored at 2–8°C, protected from light, and used within 30 days. Lyophilised vials are stable at 2–8°C until reconstitution. For full handling guidance, see our peptide storage research guide.

Where does Optic Labs ship to?

Optic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.

Legal disclaimer

All products on this site are supplied for laboratory research, development or analytical use only. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the Therapeutic Goods Administration (TGA) or the APVMA and are not intended to diagnose, treat, cure or prevent any disease.

Optic Labs is not a compounding pharmacy or manufacturing facility as defined under the Therapeutic Goods Act 1989, and is not a registered provider of scheduled medicines or therapeutic goods.