KPV 10mg

Buy high-purity KPV in Australia (10mg). Third-party lab tested at >99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.

About KPV

KPV is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH), composed of the sequence lysine–proline–valine. The peptide retains many of the anti-inflammatory and immunomodulatory characteristics attributed to the parent α-MSH molecule, but in a much smaller, more chemically tractable form. KPV has become a focal point for laboratory investigation of melanocortin-pathway-independent anti-inflammatory mechanisms, particularly in epithelial and mucosal tissue models.

Optic Labs supplies KPV as a lyophilised research-grade powder for laboratories investigating gut-barrier integrity, dermal inflammation, mast-cell behaviour, and innate-immune signalling. Each vial is third-party HPLC verified at >99% purity. KPV peptide is supplied for laboratory research use only and is not intended for human consumption, cosmetic application, or any therapeutic purpose.

Product specifications

• Compound: KPV (Lysine–Proline–Valine)
• CAS number: 67727-97-3
• Molecular formula: C₁₆H₃₀N₄O₄
• Molecular weight: ~342.4 g/mol
• Sequence: Lys-Pro-Val (KPV)
• Form: Lyophilised powder
• Purity: >99% by HPLC
• Available sizes: 10mg vial
• Storage: 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.
• Origin: Manufactured to research-grade specifications, third-party HPLC verified
• Shipping: Australia-wide domestic dispatch from Sydney, NSW

Research background

KPV was first characterised in the 1980s and 1990s as a minimal active fragment of α-MSH (α-melanocyte-stimulating hormone), retaining anti-inflammatory activity in the apparent absence of melanocortin-receptor binding. This made KPV an unusual research tool — a small peptide capable of modulating inflammation through receptor-independent intracellular pathways. Since then, the peptide has appeared across multiple lines of preclinical inflammation research.

• NF-κB pathway modulation — in cell-culture studies, KPV has been reported to interfere with NF-κB nuclear translocation, an upstream regulator of pro-inflammatory cytokine transcription.
• Colitis and gut-barrier models — published animal studies in DSS- and TNBS-induced colitis have explored KPV as a candidate for restoring intestinal epithelial integrity and reducing mucosal inflammation.
• Mast-cell activity — preclinical work has examined the peptide's effect on mast-cell degranulation and histamine-mediated inflammatory cascades.
• Dermal and atopic models — KPV has been investigated topically in animal models of contact dermatitis and atopic-style skin inflammation.
• PepT1 transporter uptake — research has characterised KPV as a substrate for the intestinal PepT1 di/tripeptide transporter, supporting its use in oral-delivery research.
• Cytokine profiling — laboratory investigations have profiled changes in TNF-α, IL-6, and IL-1β following KPV exposure in inflammatory cell models.
• Anti-microbial activity — fragment-based research has reported activity against certain dermatophyte and yeast species in vitro.

For a more detailed research summary, see our KPV anti-inflammatory research guide and our broader what are peptides explainer. Researchers working with reconstitution should also reference our peptide reconstitution guide.

Reconstitution and handling

KPV is supplied as a lyophilised powder and is reconstituted prior to use with sterile bacteriostatic water. A common laboratory approach is to add 2 mL of bac water to a 10mg vial, yielding a 5 mg/mL working concentration; at this concentration, 0.1 mL drawn into an insulin syringe corresponds to 500 µg of peptide. Reconstituted KPV should be stored at 2–8°C, protected from light, and used within 30 days. For step-by-step dilution mathematics, see our reconstitution calculator guide and our peptide storage research guide.

Commonly stacked research peptides

In published stack-design literature, KPV is frequently grouped with other peptides under investigation for tissue-repair, gut-barrier, and skin-inflammation research. Researchers commonly cross-reference:

• BPC-157 — gastric-derived pentadecapeptide investigated for gut-barrier and angiogenesis research, often paired with KPV in mucosal-integrity work.
• TB-500 — thymosin β4 fragment used in tissue-repair research, complementing KPV in injury and inflammation models.
• GHK-Cu — copper-binding tripeptide investigated for dermal remodelling, often referenced alongside KPV in skin-inflammation research.
• KLOW80 stack — pre-formulated combination of BPC-157, GHK-Cu, TB-500 and KPV used in stack-design research.
• Glutathione — tripeptide antioxidant cross-referenced with KPV in redox and inflammation research designs.

For more on multi-peptide research designs, see our peptide research stacks overview.

Frequently asked questions

Is KPV legal in Australia?

KPV is supplied by Optic Labs strictly for laboratory research, development and analytical use. It is not approved by the Therapeutic Goods Administration for human therapeutic use and is not a registered medicine. For a detailed overview of Australian peptide research regulation, see our guide to peptide legality and TGA compliance in Australia.

What is KPV?

KPV is a synthetic tripeptide consisting of the amino acids lysine, proline and valine — the C-terminal three residues of α-melanocyte-stimulating hormone (α-MSH). It is studied in laboratory research for its anti-inflammatory and immunomodulatory characteristics. See our what are peptides explainer for broader context.

What does KPV research focus on?

Published research has examined KPV in cell-culture and animal models of intestinal inflammation, dermatitis, mast-cell activation and NF-κB-mediated cytokine signalling. The peptide is studied as a small, receptor-independent anti-inflammatory tool rather than a melanocortin-pathway agonist.

How is KPV supplied?

Optic Labs supplies KPV as a lyophilised powder in glass research vials, available in 10mg. Each vial is sealed and shipped with a tamper-evident seal. Certificates of analysis showing HPLC purity testing are available on request.

How much bacteriostatic water do I mix with a KPV 10mg vial?

A common laboratory dilution is 2 mL of bacteriostatic water per 10mg vial, giving a 5 mg/mL solution. The exact volume depends on your research protocol — see our reconstitution calculator guide for dilution mathematics.

How should reconstituted KPV be stored?

Reconstituted KPV should be kept at 2–8°C, protected from light, and used within 30 days. Long-term storage of unreconstituted lyophilised powder should be at −20°C or colder. See our peptide storage complete research guide for handling detail.

Where does Optic Labs ship to?

Optic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.

Legal disclaimer

All products on this site are supplied for laboratory research, development or analytical use only. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the Therapeutic Goods Administration (TGA) or the APVMA and are not intended to diagnose, treat, cure or prevent any disease. Optic Labs is not a compounding pharmacy or manufacturing facility as defined under the Therapeutic Goods Act 1989, and is not a registered provider of scheduled medicines or therapeutic goods.