Thymosin Alpha-1 10mg

Buy high-purity Thymosin Alpha-1 in Australia (10mg). Third-party lab tested at >99% purity. Australian-domestic shipping, AUD pricing, supplied for laboratory research use only.

About Thymosin Alpha-1

Thymosin Alpha-1 (Tα1, also written as thymosin α-1 or TA-1) is a 28-amino-acid acetylated peptide derived from the N-terminus of prothymosin α. First isolated from calf thymus by Allan Goldstein and colleagues in 1977, Tα1 has been characterised in published research as one of the most-studied immunomodulatory peptides, with a body of literature spanning toll-like-receptor signalling, T-cell maturation and cytokine modulation in cell-culture and animal models.

Optic Labs supplies Thymosin Alpha-1 in Australia as a lyophilised powder, 10mg per vial, third-party HPLC verified at >99% purity. The compound is provided strictly for laboratory research, including in-vitro innate-immunity assays, cell-culture cytokine-profiling work and animal studies of viral, oncological and immune-deficiency models. Thymosin Alpha-1 is supplied for research use only and is not intended for human consumption, clinical, cosmetic, diagnostic or veterinary application.

Product specifications

• Compound: Thymosin Alpha-1 (Tα1, TA-1)
• CAS number: 62304-98-7
• Molecular formula: C₁₂₉H₂₁₅N₃₃O₅₅
• Molecular weight: ~3108.3 g/mol
• Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28-mer, N-terminal acetylated)
• Form: Lyophilised powder
• Purity: >99% by HPLC
• Available sizes: 10mg vial
• Storage: 2–8°C, protect from light. Reconstituted: 2–8°C, used within 30 days.
• Origin: Manufactured to research-grade specifications, third-party HPLC verified
• Shipping: Australia-wide domestic dispatch from Sydney, NSW

Research background

Thymosin Alpha-1 has been a tool of choice for immunomodulatory peptide research for nearly five decades. The peptide signals through toll-like receptor 9 (TLR9) and TLR2 in published research, modulating innate-immunity pathways and influencing T-cell development. Tα1 has progressed through clinical research programmes for chronic hepatitis B and C, sepsis and certain immunocompromised states in some jurisdictions, and remains a widely cited reference compound in laboratory immunology research.

• TLR9 and TLR2 signalling research in dendritic cells and macrophage cell-culture models.
• T-cell maturation and Th1-skewing studies in thymic stromal and peripheral T-cell research models.
• Natural killer (NK) cell activity and cytokine-profiling research in cultured peripheral blood mononuclear cells.
• Antiviral pathway research in cell-culture models of hepatitis B, hepatitis C and respiratory viral infection.
• Sepsis and critical-illness immunology research in rodent models examining immunoparalysis and recovery dynamics.
• Oncology-adjacent research on Tα1 as an immunomodulatory adjunct in animal-tumour models.
• Vaccine-adjuvant research in rodent immunisation models examining antibody titres and cellular response.

For broader peptide-research context, see our what are peptides explainer and our peptide research stacks overview. Researchers working with reconstitution should also reference our peptide reconstitution guide.

Reconstitution and handling

Thymosin Alpha-1 is supplied lyophilised and should be reconstituted with sterile bacteriostatic water for laboratory use. A common working approach is to add 2mL of bacteriostatic water to a 10mg vial, yielding a 5mg/mL stock; 1mL gives 10mg/mL for more concentrated workflows. Add the diluent slowly down the side of the vial — do not inject directly onto the lyophilised cake — and allow the powder to dissolve without vigorous shaking. Reconstituted Tα1 should be stored at 2–8°C, protected from light, and used within 30 days. For a step-by-step volume calculator and worked examples for any vial size, see our peptide reconstitution calculator guide and our peptide storage guide.

Commonly stacked research peptides

Thymosin Alpha-1 is frequently studied alongside other peptides relevant to immunomodulatory, anti-inflammatory and tissue-repair pathways:

• KPV — α-MSH-derived tripeptide examined in NF-κB modulation and gut-barrier research, complementary to Tα1 in inflammation-research designs.
• BPC-157 — pentadecapeptide widely studied in tissue-repair models, often paired with immunomodulatory tools.
• TB-500 — thymosin β-4 fragment; researchers commonly examine the thymosin α and β families in parallel for context.
• Glutathione — endogenous antioxidant tripeptide used as a reference compound in oxidative-stress and immune-cell-redox assays.
• Selank — tuftsin-derived heptapeptide examined in immunomodulatory and anxiolytic research.

For broader stack-design context, see our peptide research stacks overview.

Frequently asked questions

Is Thymosin Alpha-1 legal in Australia?

Thymosin Alpha-1 is not an approved therapeutic good in Australia and is not registered with the Therapeutic Goods Administration (TGA). Optic Labs supplies Tα1 strictly for laboratory research, development and analytical use — not for human consumption, clinical or cosmetic application. For a detailed overview of how research peptides sit within the Australian regulatory framework, see our guide to peptide legality and TGA compliance in Australia.

What is Thymosin Alpha-1?

Thymosin Alpha-1 is a 28-amino-acid acetylated peptide derived from the N-terminus of prothymosin α, originally isolated from calf thymus in 1977. It is one of the most extensively studied immunomodulatory peptides in published research, with a literature spanning TLR9/TLR2 signalling, T-cell maturation and cytokine modulation. For a plain-language overview of peptide structure and research use, see our what are peptides explainer.

How does Thymosin Alpha-1 differ from TB-500 (thymosin β-4)?

Despite their similar names, the two peptides come from distinct families and are studied for different purposes. Thymosin Alpha-1 is a 28-amino-acid α-thymosin investigated in immunomodulatory research — TLR signalling, T-cell maturation and cytokine modulation. TB-500 is a 17-amino-acid fragment of thymosin β-4, studied for actin-cytoskeleton remodelling, cell migration and tissue-repair pathways. Researchers examining both immune and repair endpoints sometimes run them in parallel rather than as substitutes — see our TB-500 research guide for context.

How much bacteriostatic water do I mix with a Thymosin Alpha-1 10mg vial?

For a 10mg vial, 2mL of bacteriostatic water gives a 5mg/mL stock; 1mL gives 10mg/mL. Choose the dilution that matches the volumes typical of your research protocol. See our reconstitution calculator guide for worked examples.

How should reconstituted Thymosin Alpha-1 be stored?

Reconstituted Tα1 should be stored at 2–8°C, protected from light, and used within 30 days. Lyophilised vials are stable at 2–8°C until reconstitution. For full handling guidance, see our peptide storage research guide.

Where does Optic Labs ship to?

Optic Labs ships Australia-wide from Sydney, NSW. Standard dispatch is next business day on orders received before the daily cut-off. International shipping is not currently offered.

Legal disclaimer

All products on this site are supplied for laboratory research, development or analytical use only. They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application. These products and statements have not been evaluated by the Therapeutic Goods Administration (TGA) or the APVMA and are not intended to diagnose, treat, cure or prevent any disease. Optic Labs is not a compounding pharmacy or manufacturing facility as defined under the Therapeutic Goods Act 1989, and is not a registered provider of scheduled medicines or therapeutic goods.